UCP2-dependent redox sensing in POMC neurons regulates feeding
Nal Ae Yoon, Sungho Jin, Jung Dae Kim, Zhong Wu Liu, Qiushi Sun, Rebecca Cardone, Richard G. Kibbey, Sabrina Diano
Abstract
mice have impaired glucose metabolism and are prone to obesity on a high-fat diet. Altogether, our data show that lactate through redox signaling and blocking mitochondrial glucose utilization activates POMC neurons to regulate feeding and glucose metabolism.
Topics & Concepts
EndocrinologyMitochondrionInternal medicineBiologyMetabolismCarbohydrate metabolismCytosolExtracellularPopulationProopiomelanocortinGlycolysisCellular respirationBiochemistryChemistryHypothalamusEnzymeDemographyMedicineSociologyAdipose Tissue and MetabolismRegulation of Appetite and ObesityPancreatic function and diabetes