Pd-Catalyzed intermolecular asymmetric allylic dearomatization of 1-nitro-2-naphthols with MBH adducts
Qingxia Zhang, Jiahao Xie, Qing Gu, Shu‐Li You
Abstract
)-L1, the reaction proceeded smoothly in 1,4-dioxane at room temperature, affording substituted β-naphthalenones in good yields (up to 92%) and enantioselectivity (up to 90% ee). A range of substituted 1-nitro-2-naphthols and MBH adducts were found to be compatible under the optimized conditions. This reaction provides a convenient method for the synthesis of enantioenriched 1-nitro-β-naphthalenone derivatives.
Topics & Concepts
NitroChemistryAdductAllylic rearrangementCatalysisIntermolecular forceMedicinal chemistryLigand (biochemistry)StereochemistryOrganic chemistryCombinatorial chemistryMoleculeBiochemistryAlkylReceptorOxidative Organic Chemistry ReactionsAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization Methods