Recent Advances in Direct C−H Trifluoromethylation of N‐Heterocycles
Gakul Baishya, Nibedita Baruah Dutta
Abstract
Abstract Fluorine chemistry executes a vital role in the agricultural, pharmaceutical, and materials industries. Moreover, introducing fluorine atom and fluorine‐containing groups onto organic compounds can enhance the chemical and physical properties of the parent molecules. Because of this reason, researchers have been putting continuous efforts into developing newer and practical methodologies to incorporate fluorinated groups into organic molecules. Mainly, molecules bearing the trifluoromethyl (−CF 3 ) group show various pharmacological and biological properties. The current review provides comprehensive coverage of the recent development on the direct trifluoromethylation of some essential N‐heterocycles involving CF 3 radicals.