Oxygen carrier in core-shell fibers synthesized by coaxial electrospinning enhances Schwann cell survival and nerve regeneration
Teng Ma, Yafeng Yang, Xin Quan, Lei Lü, Bing Xia, Jianbo Gao, Fengyu Qi, Shengyou Li, Laihe Zhao, Liangwei Mei, Yi Zheng, Yanbing Shen, Zhuojing Luo, Yan Jin, Jinghui Huang
Abstract
A synthetic oxygen carrier in core-shell fibers was fabricated by the coaxial electrospinning technique and was capable of enhancing SC survival and nerve regeneration by prolonged oxygen supply. These findings provide a new strategy for fabricating cellular scaffolds to achieve regeneration in peripheral nerve injury treatment and other aerobic tissue injuries.
Topics & Concepts
Regeneration (biology)Schwann cellCoaxialOxygenElectrospinningMaterials scienceShell (structure)Core (optical fiber)Chemical engineeringChemistryBiophysicsComposite materialCell biologyAnatomyPolymerMedicineOrganic chemistryBiologyEngineeringElectrical engineeringNerve injury and regenerationElectrospun Nanofibers in Biomedical ApplicationsMesenchymal stem cell research