In Vitro-In Vivo Correlation of Blood–Brain Barrier Permeability of Drugs: A Feasibility Study Towards Development of Prediction Methods for Brain Drug Concentration in Humans
Ryo Ito, Hanae Morio, Tomoyo Baba, Yasuyuki Sakaguchi, Naomi Wakayama, Ryuto Isogai, Yoshiyuki Yamaura, Takafumi Komori, Tomomi Furihata
Topics & Concepts
Physiologically based pharmacokinetic modellingIn vivoBlood–brain barrierPharmacologyIn vitroChemistryPharmacokineticsDrugBiologyCentral nervous systemNeuroscienceBiochemistryBiotechnologyBarrier Structure and Function StudiesDrug Transport and Resistance MechanismsFunctional Brain Connectivity Studies