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Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

Erik C. B. Johnson, Eric B. Dammer, Duc M. Duong, Lingyan Ping, Maotian Zhou, Luming Yin, Lenora A. Higginbotham, Andrew Guajardo, Bartholomew White, Juan C. Troncoso, Madhav Thambisetty, Thomas J. Montine, Edward B. Lee, John Q. Trojanowski, Thomas G. Beach, Eric M. Reiman, Vahram Haroutunian, Minghui Wang, Eric E. Schadt, Bin Zhang, Dennis W. Dickson, Nilüfer Ertekin‐Taner, Todd E. Golde, Vladislav Petyuk, Philip L. De Jager, David A. Bennett, Thomas S. Wingo, Srikant Rangaraju, Ihab Hajjar, Joshua M. Shulman, James J. Lah, Allan I. Levey, Nicholas T. Seyfried

2020Nature Medicine1,063 citationsDOIOpen Access PDF

Topics & Concepts

Cerebrospinal fluidMicrogliaAstrocyteProteomicsAlzheimer's diseaseDiseaseBiologyQuantitative proteomicsNeurosciencePathologyImmunologyMedicineCentral nervous systemInflammationBiochemistryGeneAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation | Litcius