Synergistic effect of elevated glucose levels with SARS-CoV-2 spike protein induced NOX-dependent ROS production in endothelial cells
Jiahao Zhang, He Li, Rong Huang, Juan Felipe Álvarez, David Yang, Qihao Sun, Fengqin Wang, Zhiyong Peng, Nanhui Jiang, L. Joseph Su
Topics & Concepts
Context (archaeology)Oxidative stressEndothelial dysfunctionEndothelial stem cellNOX4Endothelial activationTMPRSS2Downregulation and upregulationBiologyCell biologyChemistryNADPH oxidaseEndotheliumInternal medicineIn vitroMedicineEndocrinologyCoronavirus disease 2019 (COVID-19)BiochemistryDiseaseGeneInfectious disease (medical specialty)PaleontologyCOVID-19 Clinical Research StudiesAdvanced Glycation End Products researchBarrier Structure and Function Studies