Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis
Qianxing Zou, Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi
Abstract
null mice exhibited compromised regenerative spermatogenesis after chemical insult and early degenerative spermatogenesis in aging mice. These data demonstrate that maintaining proteostasis is important for spermatogenesis, of which ribosome homeostasis maintained by ribosomal proteins coordinates translation machinery to the regulation of cellular growth.
Topics & Concepts
ProteostasisSpermatogenesisBiologyRibosome biogenesisCell biologyRibosomeRibosomal proteinProtein biosynthesisBiogenesisGeneticsRNAEndocrinologyGeneRNA modifications and cancerUbiquitin and proteasome pathwaysRNA and protein synthesis mechanisms