NADPH oxidase 4-derived hydrogen peroxide counterbalances testosterone-induced endothelial dysfunction and migration
Juliano Alves, Rafael M. Costa, Wanessa M.C. Awata, Ariane Bruder‐Nascimento, Shubhnita Singh, Rita C. Tostes, Thiago Bruder‐Nascimento
Abstract
By inducing ROS formation, high levels of testosterone play a major role in the pathogenesis of cardiovascular disease. NOXs are the major sources of ROS in the vasculature of cardiovascular diseases. Herein, we describe a novel compensatory mechanism by showing that NOX4 is a protective oxidant enzyme and counterbalances the deleterious effects of testosterone in endothelial cells by modulating hydrogen peroxide formation.
Topics & Concepts
Hydrogen peroxideNADPH oxidaseEndothelial dysfunctionChemistryTestosterone (patch)Reactive oxygen speciesInternal medicineBiochemistryMedicineNitric Oxide and Endothelin EffectsHormonal and reproductive studiesNeutrophil, Myeloperoxidase and Oxidative Mechanisms