The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection
Kristen E. Pauken, Jernej Godec, Pamela M. Odorizzi, Keturah Brown, Kathleen B. Yates, Shin Foong Ngiow, Kelly P. Burke, Seth Maleri, Shannon Grande, Loise M. Francisco, Mohammed-Alkhatim Ali, Sabrina Imam, Gordon J. Freeman, W. Nicholas Haining, E. John Wherry, Arlene H. Sharpe
Abstract
T cells after they migrate into non-lymphoid tissues. These findings have important implications for PD-1-based immunotherapy, in which PD-1 inhibition may influence memory responses in patients.
Topics & Concepts
Priming (agriculture)CD8BlockadeCytotoxic T cellImmunologyChronic infectionT cellBiologyMemory cellMemory T cellPD-L1Immune systemImmunotherapyCancer researchReceptorGeneticsIn vitroBotanyGerminationVoltageTransistorQuantum mechanicsPhysicsImmune Cell Function and InteractionCancer Immunotherapy and BiomarkersT-cell and B-cell Immunology