Diffusion MRI fiber diameter for muscle denervation assessment
Ek T. Tan, Kelly C. Zochowski, Darryl B. Sneag
Abstract
BACKGROUND: To develop and evaluate a diffusion MRI-based apparent muscle fiber diameter (AFD) method in patients with muscle denervation. It was hypothesized that AFD differences between denervated, non-denervated and control muscles would be greater than those from standard diffusion metrics. METHODS: - and fat fraction (FF)-mapping were acquired for comparison. RESULTS: (0.359, P<0.001). CONCLUSIONS: Diffusion MRI-based AFD complements T2- and FF-mapping techniques to non-invasively assess muscle denervation.
Topics & Concepts
DenervationMedicineDiffusion MRIMuscle fibreNuclear medicineCorrelationAnatomyMathematicsMagnetic resonance imagingSkeletal muscleRadiologyGeometryAdvanced Neuroimaging Techniques and ApplicationsPeripheral Nerve DisordersVoice and Speech Disorders