ThDP-dependent enzyme catalyzed oxidation of aldehydes
Xiaoyang Chen, Meiting Zhou, Xinyu Duan, Yuting Zhang, Xiaohe Chu, Jian Xu
Abstract
) as the oxidant. The reaction exhibits high efficiency (yield up to 99% and turnover number up to 2000) and achieves effective stereoselective control for dynamic kinetic resolutions (e.e. up to 99%). This study uncovers a previously undiscovered capability of ThDP-dependent enzymes, thus broadening the functional repertoire of this enzyme class.
Topics & Concepts
BenzoinDecarboxylationThiamineEnzymeChemistryCatalysisOrganic chemistryAldehydeEnzyme catalysisBiochemistryBiochemical Acid Research StudiesAlcoholism and Thiamine DeficiencyMetabolism and Genetic Disorders