HDAC1-mediated deacetylation of HIF1α prevents atherosclerosis progression by promoting miR-224-3p-mediated inhibition of FOSL2
Hao Wang, Kazuo Sugimoto, Hao Lu, Wanyong Yang, Ji-Yue Liu, Hongyu Yang, Yuebo Song, Dong Yan, Tianyu Zou, Si Shen
Abstract
. In summary, HDAC1 overexpression may enhance the anti-atherosclerotic and endothelial-protective effects of miR-224-3p-mediated inhibition of FOSL2 by deacetylating HIF1α, underscoring a novel therapeutic insight against experimental atherosclerosis.
Topics & Concepts
ApoptosismicroRNACancer researchBiologyReactive oxygen speciesInflammationHistone deacetylaseFoam cellAcetylationCell biologyCellHistoneChemistryImmunologyMolecular biologyLipoproteinBiochemistryCholesterolGeneMicroRNA in disease regulationCancer-related molecular mechanisms researchAtherosclerosis and Cardiovascular Diseases