The discovery and evaluation of [18F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement
David J. Donnelly, Joon‐Young Kim, Tritin Tran, Paul M. Scola, Daniel J. Tenney, Adrienne Pena, Thomas Petrone, Yunhui Zhang, Kenneth M. Boy, Michael A. Poss, Erin L. Cole, Matthew G. Soars, Benjamin M. Johnson, Daniel N. Cohen, Daniel Núñez Batalla, Patrick L Chow, Andrea Olga Shorts, Shuyan Du, Nicholas A. Meanwell, Samuel J. Bonacorsi
Topics & Concepts
RadioligandIn vivoChemistryPeptideLigand (biochemistry)Ex vivoImaging agentPD-L1In vitroCancer researchReceptorMolecular biologyMedicineCancerBiochemistryBiologyInternal medicineImmunotherapyBiotechnologyCancer Immunotherapy and BiomarkersPeptidase Inhibition and AnalysisMedical Imaging Techniques and Applications