Chitooligosaccharides alleviate hepatic fibrosis by regulating the polarization of M1 and M2 macrophages
Peng Liu, Heng Li, Jin‐Song Gong, Yan Geng, Min Jiang, Hongyu Xu, Zhenghong Xu, Jin‐Song Shi
Abstract
, characterized by the raised biomarker of the M1 and M2 macrophages slipping towards the basal levels. Furthermore, COS inhibited the JAK2/STAT1 pathways on M1 macrophages and the JAK1/STAT6 pathways on M2 macrophages in KCs. In summary, this study revealed a molecular mechanism for the impact of COS effectiveness on the polarization of liver macrophages, suggesting that is could be a possible intervention for hepatic fibrosis.
Topics & Concepts
Hepatic fibrosisMacrophage polarizationChemistryFibrosisIn vivoLipopolysaccharideImmune systemM2 MacrophageSTAT6MacrophageCancer researchIn vitroCell biologyImmunologyInterleukin 4BiologyPathologyBiochemistryMedicineBiotechnologyLiver physiology and pathologyPancreatitis Pathology and TreatmentImmune cells in cancer