A Nationwide Plasmidome Surveillance in Thailand Reveals a Limited Variety of New Delhi Metallo-β-Lactamase-Producing Carbapenem-Resistant <i>Enterobacteriaceae</i> Clones and Spreading Plasmids
Ryuichiro Abe, Yukihiro Akeda, Noriko Sakamoto, Dan Takeuchi, Yo Sugawara, Norihisa Yamamoto, Anusak Kerdsin, Yuki Matsumoto, Daisuke Motooka, Warawut Laolerd, Pitak Santanirand, Masato Suzuki, Keigo Shibayama, Kazunori Tomono, Tetsuya Iida, Shigeyuki Hamada
Abstract
Despite frequent identification of plasmids carrying carbapenemase genes, the transfer of plasmids carrying carbapenemase genes is not well recognized in clinical settings because of technical limitations. To investigate the detailed mechanisms of the spread of carbapenem-resistant Enterobacteriaceae (CRE), we performed multifaceted genomic surveillance of CRE isolates in Thailand and analyzed their plasmidome.
Topics & Concepts
PlasmidEnterobacteriaceaeKlebsiella pneumoniaeBiologyMicrobiologyEscherichia coliCarbapenem-resistant enterobacteriaceaeCarbapenemMobile genetic elementsGeneGeneticsAntibioticsAntibiotic Resistance in BacteriaPlant Pathogenic Bacteria StudiesPharmaceutical and Antibiotic Environmental Impacts