The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models
Kim M. Stegmann, Antje Dickmanns, Sabrina Gerber, Vella Nikolova, Luisa Klemke, Valentina Manzini, Denise Schlösser, Cathrin Bierwirth, Julia Freund, Maren Sitte, Raimond Lugert, Gabriela Salinas, Toni Luise Meister, Stephanie Pfaender, Dirk Görlich, Bernd Wollnik, Uwe Groß, Matthias Dobbelstein
Topics & Concepts
BiologyVero cellViral replicationVirologyVirusDihydrofolate reductaseCoronavirusMethotrexateImmunologyMedicineCoronavirus disease 2019 (COVID-19)Infectious disease (medical specialty)DiseasePathologySARS-CoV-2 and COVID-19 ResearchVirus-based gene therapy researchCOVID-19 Clinical Research Studies