Hot-melt extrusion promotes dissolution, extends “spring-parachute” process and inhibits crystallization in supersaturating microparticle systems
Yanfei Zhang, Huifeng Zhang, Huan Yu, Yinghui Ma, Chengyi Hao, Xiaoying Lin, Yong Zhang, Zhengqiang Li, Xian Qi, Jia Zeng, Nianqiu Shi
Topics & Concepts
SupersaturationAmorphous solidMaterials scienceDissolutionCrystallizationChemical engineeringSolubilityExtrusionDifferential scanning calorimetryPolyvinylpyrrolidoneChemistryOrganic chemistryComposite materialThermodynamicsPolymer chemistryEngineeringPhysicsDrug Solubulity and Delivery SystemsCrystallization and Solubility StudiesAdvanced Drug Delivery Systems