Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A
Yuka Miyazaki, Masaki Kikuchi, Koji Umezawa, Aurélie Descamps, Daichi Nakamura, Gaku Furuie, Tomoe Sumida, Kanako Saito, Ninako Kimura, Takashi Niwa, Yuto Sumida, Takashi Umehara, Takamitsu Hosoya, Isao Kii
Topics & Concepts
ChemistryAutophosphorylationDYRK1AIntramolecular forceSteric effectsFolding (DSP implementation)PhosphorylationStereochemistryMoietyBiophysicsProtein kinase ABiochemistryBiologyElectrical engineeringEngineeringDown syndrome and intellectual disability researchUbiquitin and proteasome pathways