GsMTx-4 normalizes the exercise pressor reflex evoked by intermittent muscle contraction in early stage type 1 diabetic rats
Ann‐Katrin Grotle, Yu Huo, Michelle Harrison, Kai M. Ybarbo, Audrey J. Stone
Abstract
This is the first study to demonstrate that blocking Piezo channels is effective in ameliorating the exaggerated exercise pressor reflex evoked by intermittent muscle contraction, commonly occurring during physical activity, in T1DM. Thus, these findings suggest Piezo channels may serve as an effective therapeutic target to reduce the acute and prolonged cardiovascular strain that may occur during dynamic exercise in T1DM.
Topics & Concepts
Internal medicineReflexContraction (grammar)EndocrinologyMedicineTransient receptor potential channelMuscle contractionReceptorErythrocyte Function and PathophysiologyIon channel regulation and functionPain Mechanisms and Treatments