Phytochemicals for the treatment of COVID-19
Erica Españo, Jiyeon Kim, Kiho Lee, Jeong-Ki Kim
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has underscored the lack of approved drugs against acute viral diseases. Plants are considered inexhaustible sources of drugs for several diseases and clinical conditions, but plant-derived compounds have seen little success in the field of antivirals. Here, we present the case for the use of compounds from vascular plants, including alkaloids, flavonoids, polyphenols, and tannins, as antivirals, particularly for the treatment of COVID-19. We review current evidence for the use of these phytochemicals against SARS-CoV-2 infection and present their potential targets in the SARS-CoV-2 replication cycle.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)PandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakPolyphenolCoronavirusBiologyDiseaseVirologyMedicineTraditional medicineInfectious disease (medical specialty)Internal medicineBiochemistryAntioxidantOutbreakDrug-Induced Hepatotoxicity and ProtectionEssential Oils and Antimicrobial ActivityPhytochemicals and Medicinal Plants