LncRNA Snhg1-driven self-reinforcing regulatory network promoted cardiac regeneration and repair after myocardial infarction
Mengsha Li, Hao Zheng, Yuan Han, Yijin Chen, Bing Li, Guojun Chen, Xiaoqiang Chen, Senlin Huang, Xiang He, Guoquan Wei, Tong Xu, Xiaofei Feng, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin
Abstract
Snhg1 effectively elicited CM proliferation and improved cardiac function post-MI by forming a positive feedback loop with c-Myc to sustain PI3K/Akt signaling activation, and thus may be a promising cardiac regeneration strategy in treating heart failure post-MI.
Topics & Concepts
TensinPTENPI3K/AKT/mTOR pathwayProtein kinase BBiologyCell biologyRegeneration (biology)Cardiac function curveCell growthKinaseSignal transductionCancer researchInternal medicineMedicineHeart failureBiochemistryCongenital heart defects researchCancer-related molecular mechanisms researchCardiac Valve Diseases and Treatments