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Innovative Strategies for Plant Protection: The Combination of Spray-Induced Gene Silencing and Nanotechnology

Yitao Xi, Sawera Akram, Xinyi Yang, Beibei Hu, Muhammad Abu Bakar Saddique, Ge Guan, Donglan Tian, Xiumei Luo, Maozhi Ren

2025Journal of Agricultural and Food Chemistry14 citationsDOI

Abstract

Chemical pesticides have traditionally been a primary strategy for controlling plant diseases. With the mounting issues in disease control arising from the prolonged use of pesticides, the three ″R″ issues (resistance, residues, and resurgence) and the three ″risks″ (disability, teratogenicity, and mutagenicity) have become more prominent, significantly hindering agricultural development. There is an urgent need to develop sustainable and environmentally friendly approaches to prevent and control plant diseases. RNA pesticides are poised to lead a green revolution in agriculture, and spray-induced gene silencing (SIGS), depending on dsRNA and nanotechnology, is a novel approach offering efficient and targeted strategies for sustainable management of plant pathogens. The technology avoids the potential ecological risks associated with genetically modified crops. This review outlines the recent progress in understanding the molecular mechanisms of dsRNA silencing in plant pathogens and focuses on the advancements in SIGS using nanotechnology for managing plant diseases. The combination of SIGS with nanopesticide will provide a dual effect on disease control.

Topics & Concepts

BiotechnologyEnvironmentally friendlyPlant diseaseRNA silencingAgricultureGene silencingSustainable agricultureNanotechnologyRNA interferenceBiologyRisk analysis (engineering)BusinessRNAEcologyGeneGeneticsMaterials sciencePlant Virus Research StudiesPlant Disease Management TechniquesPlant and Fungal Interactions Research