Copper(<scp>ii</scp>)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm
Yaoxin Zhang, Linpei Li, Hui Liu, Haixia Zhang, Menghao Wei, Junqing Zhang, Yanwei Yang, Mengnan Wu, Zhaowei Chen, Chaoqun Liu, Faming Wang, Qiang Wu, Jiahua Shi
Abstract
A maximum GSH-depleting photodynamic nanosystem was developed by loading Cu 2+ into porphyrin MOF. Both in vitro and in vivo results indicate MOF@Cu 2+ could obliterate biofilm infection and facilitate wound healing with no distinct side effects.
Topics & Concepts
BiofilmGlutathionePorphyrinPhotodynamic therapyReactive oxygen speciesMicrobiologyChemistryBacteriaBiologyBiochemistryGeneticsEnzymeOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesHeme Oxygenase-1 and Carbon Monoxide