Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors
Chenglan Li, Yang Liu, Shanchao Wu, Guiyan Han, Jie Tu, Guoqiang Dong, Na Liu, Chunquan Sheng
Topics & Concepts
Virulence factorChemistryVirulenceIn vivoMicrobiologyDocking (animal)ProteaseVirtual screeningBiofilmEnzymePharmacologyBiochemistryBiologyDrug discoveryGeneBacteriaGeneticsMedicineBiotechnologyNursingAntifungal resistance and susceptibilityMicrobial Natural Products and BiosynthesisFungal Biology and Applications