Full-length ORF2 sequence-based genetic and phylogenetic characterization of Korean feline caliciviruses
Sung Jae Kim, Cheong-Ung Kim, Hee‐Chun Chung, Yong Ho Park, Kun Taek Park
Abstract
Feline calicivirus (FCV) is a highly infectious pathogen in cats and widely distributed worldwide with high genetic variation. Full-length open reading frame 2 of 5 from recently isolated Korean FCV isolates were sequenced and compared with those of global isolates. The results of phylogenetic analysis supported dividing global FCV isolates into two genogroups (type I and II) and demonstrated the presence of genogroup II in Korea, indicating their geographic spread in East Asia. High sequence variations in region E of the FCV isolates emphasizes that a novel vaccine needs to be developed to induce protective immunity against various FCV strains.
Topics & Concepts
Feline calicivirusPhylogenetic treeBiologyVirologyCATSOpen reading framePhylogeneticsGenetic diversityGeneticsGenetic variationGeneMedicinePeptide sequenceVirusEnvironmental healthInternal medicinePopulationViral gastroenteritis research and epidemiologyVector-Borne Animal DiseasesAnimal Virus Infections Studies