A novel proangiogenic B cell subset is increased in cancer and chronic inflammation
Willem van de Veen, Anna Głobińska, Kirstin Jansen, Alex Straumann, Terufumi Kubo, Daniëlle Verschoor, Oliver F. Wirz, Francesc Castro-Giner, Ge Tan, Beate Rückert, Urs A. Ochsner, Marietta Herrmann, Barbara Stanić, Marloes van Splunter, Daan W. Huntjens, Alexandra Wallimann, Rodney J. Fonseca Guevara, Hergen Spits, Desislava Ignatova, Yun‐Tsan Chang, Christina Fassnacht, Emmanuella Guenova, Lukas Flatz, Cezmi A. Akdiş, Mübeccel Akdiş
Abstract
B cells expressing proangiogenic cytokines were detected in patients with EoE and melanoma. Our results demonstrate a previously unidentified proangiogenic B cell subset characterized by expression of CD49b, CD73, and proangiogenic cytokines.
Topics & Concepts
CytokineAngiogenesisBiologyCancer researchB cellCD49bImmunologyImmune systemT cellAntibodyAntigen-presenting cellEosinophilic EsophagitisIL-33, ST2, and ILC PathwaysMast cells and histamine