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RBP EIF2S2 Promotes Tumorigenesis and Progression by Regulating MYC-Mediated Inhibition via FHIT-Related Enhancers

Jiwei Zhang, Shengli Li, Ling Zhang, Juan Xu, Mingxu Song, Tingting Shao, Zhaohui Huang, Yongsheng Li

2021Molecular Therapy13 citationsDOIOpen Access PDF

Abstract

(Mol Ther. 28, 1105–1118; April 8, 2020) In the originally published version of this article, Figure 2I has errors as a result of incorrect image files being used to compose the panel. The corrected Figure 2I now appears below. These corrections do not change the conclusions of the paper. The authors regret this error.Figure 2IEIF2S2 Increases GI Cancer Cell Proliferation, Invasion, and Metastasis In Vitro and In Vivo (Original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) RBP EIF2S2 Promotes Tumorigenesis and Progression by Regulating MYC-Mediated Inhibition via FHIT-Related EnhancersZhang et al.Molecular TherapyFebruary 6, 2020In BriefRNA-binding proteins play important roles in cancer. Li et al. integrated multiple omics data that identified a potential oncogene, EIF2S2. Functional analyses provided detail knowledge of the function of the EIF2S2-LINC01600-MYC axis in gastrointestinal cancer, which will help the development of combination therapies for cancer. Full-Text PDF Open Archive

Topics & Concepts

CarcinogenesisOncogeneEnhancerCancerCancer researchBiologyIn vitroMetastasisFHITRegretIn vivoGeneticsComputer scienceGeneCell cycleGene expressionTumor suppressor geneMachine learningProtein Degradation and InhibitorsCancer-related gene regulationPeptidase Inhibition and Analysis
RBP EIF2S2 Promotes Tumorigenesis and Progression by Regulating MYC-Mediated Inhibition via FHIT-Related Enhancers | Litcius