A novel CSN5/CRT O-GlcNAc/ER stress regulatory axis in platinum resistance of epithelial ovarian cancer
Tianqing Yan, Xiaolu Ma, Kaixia Zhou, Jiazhen Cao, Yanan Tian, Hui Zheng, Ying Tong, Suhong Xie, Yanchun Wang, Lin Guo, Renquan Lu
Abstract
This study reveals that CSN5-mediated aberrant O-GlcNAc-CRT acts as a crucial ER stress checkpoint, governing cell fate response to stress, and emphasizes an unrecognized role for the CSN5/CRT O-GlcNAc/ER stress axis in platinum resistance of EOC.
Topics & Concepts
BiologyGene knockdownCancer researchProtein subunitUnfolded protein responseProteomicsEndoplasmic reticulumCell biologyApoptosisGeneGeneticsGlycosylation and Glycoproteins ResearchGalectins and Cancer BiologyEndoplasmic Reticulum Stress and Disease