Biological promiscuity of a binuclear Cu(<scp>ii</scp>) complex of aminoguanidine Schiff base: DNA binding, anticancer activity and histidine sensing ability of the complex
Antu Mondal, Chandrima Das, M. Corbella, Antonio Bauzá, Antonio Frontera, Moumita Saha, Sanchaita Mondal, Krishna Das Saha, Shyamal Kumar Chattopadhyay
Abstract
A binuclear Cu(<sc>ii</sc>) complex of aminoguanidine shows strong DNA binding activity and encouraging anti-cancer activity against HCT-16 cells. The complex can also be used for selective spectrophotomteric or fluorometric determination of histidine.
Topics & Concepts
ChemistrySchiff baseHistidineDNAStereochemistryCombinatorial chemistryBiochemistryEnzymeMetal complexes synthesis and propertiesDNA and Nucleic Acid ChemistryMetal-Catalyzed Oxygenation Mechanisms