A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects
Erwei Zuo, Yidi Sun, Tanglong Yuan, Bingbing He, Changyang Zhou, Wenqin Ying, Jing Liu, Wei Wu, Rong Zeng, Yixue Li, Hui Yang
Topics & Concepts
CytosineDNACas9RNAPoint mutationComputational biologyBase pairCRISPRBiologyGenome editingMutationGeneticsGeneCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesCytomegalovirus and herpesvirus research