Evaluation of Drug–Drug Interactions in Pharmacoepidemiologic Research
Cheng Chen, Thanh Phuong Pham Nguyen, John E. Hughes, Sean Hennessy, Charles E. Leonard, Todd A. Miano, Antonios Douros, Joshua J. Gagne, Katsiaryna Bykov
Abstract
Drug-drug interactions (DDIs) represent a significant concern for clinical care and public health, but the health consequences of many DDIs remain largely underexplored. This knowledge gap underscores the critical need for pharmacoepidemiologic research to evaluate real-world health outcomes of DDIs. In this review, we summarize the definitions commonly used in pharmacoepidemiologic DDI studies, discuss common sources of bias, and illustrate through examples how these biases can be mitigated.
Topics & Concepts
MedicinePharmacoepidemiologyDrugPublic healthPharmacologyMedical prescriptionNursingPharmaceutical Practices and Patient OutcomesPharmacogenetics and Drug MetabolismPharmaceutical studies and practices