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Modulation of the crosstalk between Keap1/Nrf2/HO-1 and NF-κB signaling pathways by Tomatidine protects against inflammation/oxidative stress-driven fulminant hepatic failure in mice

Wesam H. Abdulaal, Ulfat M. Omar, Mustafa Zeyadi, Dina S. El‐Agamy, Nabil A. Alhakamy, Sabrin R. M. Ibrahim, Naif A. R. Almalki, Hani Z. Asfour, Mohammed W. Al-Rabia, Gamal A. Mohamed, Mahmoud Elshal

2024International Immunopharmacology16 citationsDOI

Topics & Concepts

Downregulation and upregulationOxidative stressFulminant hepatic failureHepatocyteInflammationLipopolysaccharideLiver injuryTumor necrosis factor alphaKEAP1EndocrinologyPharmacologyBiologyInternal medicineImmunologyMedicineTransplantationBiochemistryLiver transplantationGeneIn vitroTranscription factorDrug-Induced Hepatotoxicity and ProtectionGenomics, phytochemicals, and oxidative stressLiver Disease and Transplantation
Modulation of the crosstalk between Keap1/Nrf2/HO-1 and NF-κB signaling pathways by Tomatidine protects against inflammation/oxidative stress-driven fulminant hepatic failure in mice | Litcius