A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection
Jean‐Laurent Casanova, Helen C. Su, Laurent Abel, Alessandro Aiuti, Saleh Al‐Muhsen, Andrés A. Arias, Paul Bastard, Catherine M. Biggs, Dusan Bogunovic, Bertrand Boisson, Stéphanie Boisson‐Dupuis, Alexandre Bolze, Anastasia Bondarenko, Aziz Bousfiha, Petter Brodin, Jacinta Bustamante, Manish J. Butte, Giorgio Casari, Michael J. Ciancanelli, Aurélie Cobat, Antônio Condino‐Neto, Megan A. Cooper, Clifton L. Dalgard, Sara Espinosa, Hagit Baris Feldman, Jacques Fellay, José Luis Franco, David Hagin, Yuval Itan, Emmanuelle Jouanguy, C. Lucas, Davood Mansouri, Isabelle Meyts, Joshua D. Milner, Trine H. Mogensen, Tomohiro Morio, Lisa F. P. Ng, Luigi D. Notarangelo, Satoshi Okada, Tayfun Özçelık, Pere Soler‐Palacín, Anna M. Planas, Carolina Prando, Anne Puel, Aurora Pujol, Claire Redin, Laurent Rénia, Carlos Rodríguez‐Gallego, Lluís Quintana‐Murci, Vanessa Sancho‐Shimizu, Vijay G. Sankaran, Mikko Seppänen, Mohammad Shahrooei, Andrew L. Snow, András N. Spaan, Stuart G. Tangye, Jordi Pérez‐Tur, Stuart E. Turvey, Donald C. Vinh, Horst von Bernuth, Xiaochuan Wang, Paweł Zawadzki, Qian Zhang, Shen‐Ying Zhang
Abstract
SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers-individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease-present a unique opportunity to reveal human genetic determinants of infection and disease.