Mitochondrial UPR is required for resveratrol mediated anti-bacterial immunity
Yan Zhang, Xiaocong Li, Rui Zhao, Wanting Hu, Xin Xiao, Yi Xiao, Fang Liu
Abstract
axis as a novel mechanism through which resveratrol enhances innate immunity, providing a foundation for developing natural compound-based anti-infective therapies. These findings advance our understanding of plant polyphenols in immune regulation and offer potential strategies to address antibiotic resistance.
Topics & Concepts
ResveratrolInnate immune systemDownregulation and upregulationCell biologyImmunityChemistryCytotoxicityImmune systemBiologyMechanism (biology)AntimicrobialMitochondrionApoptosisAntimicrobial peptidesBiochemistryPolyphenolNF-κBMechanism of actionMicrobiologyMitochondrial respiratory chainPhytoalexinSirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsEndoplasmic Reticulum Stress and Disease