Intravitreal injection of anti-miRs against miR-142-3p reduces angiogenesis and microglia activation in a mouse model of laser-induced choroidal neovascularization
Quentin Roblain, Thomas Louis, Cassandre Yip, Louis Baudin, Ingrid Struman, Vincenza Caolo, Vincent Lambert, Julie Lecomte, Agnès Noël, Stéphane Heymans
Abstract
, miR-142-3p overexpression in human microglia cells (HMC3) modulated microglia activation, as shown by CD68 levels. Interestingly, miR142-3p modulation also regulated the production of VEGF-A, the main pro-angiogenic factor. Together, these data strongly support the unprecedented importance of miR-142-3p-dependent vascular-inflammation axis during CNV progression, through microglia activation.
Topics & Concepts
MicrogliaChoroidal neovascularizationInflammationAngiogenesisNeovascularizationMacular degenerationBiologyCell biologyCancer researchMedicineNeuroscienceImmunologyOphthalmologyRetinal Diseases and TreatmentsNeuroinflammation and Neurodegeneration MechanismsConnexins and lens biology