Optimized PCR-Based Enrichment Improves Coverage Uniformity and Mutation Detection in Mitochondrial DNA Next-Generation Sequencing
Yang Liu, Shanshan Guo, Chun Yin, Xu Guo, Manling Liu, Zhidong Yuan, Zheng Zhao, Yongfeng Jia, Jinliang Xing
Topics & Concepts
AmpliconMitochondrial DNABiologyPrimer (cosmetics)GeneticsDNA sequencingPolymerase chain reactionMultiple displacement amplificationSequencing by ligationAmplicon sequencingIon semiconductor sequencingIn silico PCRComputational biologyMolecular biologyDNAMultiplex polymerase chain reactionGeneDNA extractionGenomic libraryBase sequenceChemistryOrganic chemistry16S ribosomal RNAMolecular Biology Techniques and ApplicationsGenomics and Phylogenetic StudiesRNA and protein synthesis mechanisms