Role of Oxygen and Nitrogen Radicals in the Mechanism of Anticancer Drug Cytotoxicity.
Birandra K. Sinha
Abstract
. However, the importance of RNS in cancer treatment is not clear and has remained poorly defined. This review discusses the current understanding of the formation and the significance of ROS and RNS in the mechanisms of various clinically active anticancer drugs.
Topics & Concepts
Reactive oxygen speciesCytotoxicityDrugPharmacologyEtoposideIn vivoMechanism (biology)DoxorubicinCancer researchMechanism of actionTopotecanDrug resistanceMedicineChemistryBiologyIn vitroChemotherapyBiochemistryBiotechnologyInternal medicineMicrobiologyPhilosophyEpistemologyBioactive Compounds and Antitumor AgentsCancer therapeutics and mechanismsSynthesis and biological activity