Tertiary lymphoid structure and decreased CD8+ T cell infiltration in minimally invasive adenocarcinoma
Jin Wang, Dongbo Jiang, Xiaoqi Zheng, Wang Li, Tian Zhao, Di Wang, Huansha Yu, Dongqing Sun, Ziyi Li, Jian Zhang, Zhe Zhang, Likun Hou, Gening Jiang, Ke Fei, Fan Zhang, Kun Yang, Peng Zhang
Abstract
T cell infiltration and attenuated anti-tumor immunity in MIA. Our study demonstrates how integrating transcriptome and pathology characterize TME and elucidate potential mechanisms of tumor immune evasion.
Topics & Concepts
Infiltration (HVAC)CD8Tumor microenvironmentAdenocarcinomaBiologyImmune systemPathologyImmunohistochemistryCancer researchTumor-infiltrating lymphocytesT cellImmunologyMedicineCancerThermodynamicsPhysicsGeneticsCancer Immunotherapy and BiomarkersSingle-cell and spatial transcriptomicsImmunotherapy and Immune Responses