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Enhanced bone regeneration <i>via</i> PHA scaffolds coated with polydopamine-captured BMP2

Xu Zhang, Jian Li, Jin Chen, Zixin Peng, Jiangnan Chen, Xin-Yi Liu, Fuqing Wu, Peng Zhang, Guo‐Qiang Chen

2022Journal of Materials Chemistry B36 citationsDOI

Abstract

3D-printed scaffolds of polyhydroxyalkanoate (PHA) are functionalized using polydopamine (PDA)-mediated recombinant human bone morphogenetic protein-2 (BMP2) to generate high osteoinductive activity for in vivo bone regeneration.

Topics & Concepts

Bone morphogenetic protein 2PolyhydroxyalkanoatesRegeneration (biology)Materials scienceIn vivoBone morphogenetic proteinRecombinant DNAHuman boneScaffoldBiomedical engineeringNanotechnologyIn vitroChemistryCell biologyBiochemistryBiotechnologyEngineeringBiologyGeneticsBacteriaGenePolymer Surface Interaction StudiesBone Tissue Engineering MaterialsGraphene and Nanomaterials Applications
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