Visible-light-induced defluorinative allylation of difluoromethyl ketones using alkylamines as bifunctional agents
Xiaorui Jiao, Zhonghou Huang, Weidong Meng, Shengqing Zhu, Lingling Chu
Abstract
A visible-light-induced alkylamine-facilitated reductive defluoroallylation of difluoromethyl ketones with allylic chlorides is reported, enabling efficient access to α-fluoro alkenylketones with high efficiency.
Topics & Concepts
ChemistryBifunctionalAllylic rearrangementVisible spectrumCombinatorial chemistryPhotochemistryMedicinal chemistryOrganic chemistryCatalysisOptoelectronicsPhysicsFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods