Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains
Khloe S. Gordon, Taeyoon Kyung, Caleb R. Perez, Patrick V. Holec, Azucena Ramos, Angela Q. Zhang, Yash Agarwal, Yunpeng Liu, Catherine Koch, Alina Starchenko, Brian A. Joughin, Douglas A. Lauffenburger, Darrell J. Irvine, Michael T. Hemann, Michael E. Birnbaum
Topics & Concepts
Chimeric antigen receptorCD19Jurkat cellsBiologyCD28T-cell receptorAntigenIntracellularReceptorComputational biologyFlow cytometryCell sortingImmunologyT cellCell biologyCancer researchImmune systemGeneticsCD8CAR-T cell therapy researchImmunotherapy and Immune ResponsesImmune Cell Function and Interaction