Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/keap1 pathway
Lun Wang, Xiaoying Cai, Mingsong Shi, Linlin Xue, Shuang Yuan Kuang, Ruiling Xu, Wenyan Qi, Yan Li, Xu Ma, Ruijia Zhang, Feng Hong, Haoyu Ye, Lijuan Chen
Topics & Concepts
NeuroprotectionChemistryTyrosine hydroxylaseMPTPPharmacologyDopaminergicPiperineParkinson's diseaseCytoprotectionDopamineOxidative stressAntioxidantSubstantia nigraBiochemistryEnzymeNeuroscienceInternal medicineMedicineDiseasePsychologyPiperaceae Chemical and Biological StudiesGenomics, phytochemicals, and oxidative stressCholinesterase and Neurodegenerative Diseases