Implications of phase solubility/miscibility and drug-rich phase formation on the performance of co-amorphous materials: The case of Darunavir co-amorphous materials with Ritonavir and Indomethacin as co-formers
Sushant Shete, Sai Charan Reddy, Yarlagadda Dani Lakshman, Sai Krishna Anand Vullendula, Chetan Hasmukh Mehta, Usha Y. Nayak, Swapnil J. Dengale
Topics & Concepts
DarunavirSolubilityAmorphous solidMiscibilityChemistryMole fractionSupersaturationPhase (matter)Organic chemistryPhysical chemistryPolymerHuman immunodeficiency virus (HIV)Viral loadAntiretroviral therapyMedicineFamily medicineCrystallization and Solubility StudiesDrug Solubulity and Delivery SystemsPharmacological Effects of Natural Compounds