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Discovery and optimization of 2,3-diaryl-1,3-thiazolidin-4-one-based derivatives as potent and selective cytotoxic agents with anti-inflammatory activity

Ahmed M. Shawky, Faisal A. Almalki, Ashraf N. Abdalla, Bahaa G. M. Youssif, Maha M. Abdel‐Fattah, Fatema Hersi, Hany A.M. El-Sherief, A. Ibrahim Nashwa, Ahmed M. Gouda

2023European Journal of Medicinal Chemistry14 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryCytotoxicityCytotoxic T cellTubulinIC50MTT assayApoptosisIn vitroStereochemistryColchicineCancer cellMicrotubulePharmacologyBiochemistryCancerBiologyMedicineInternal medicineCell biologySynthesis and biological activitySynthesis and Biological Evaluation
Discovery and optimization of 2,3-diaryl-1,3-thiazolidin-4-one-based derivatives as potent and selective cytotoxic agents with anti-inflammatory activity | Litcius