Transcriptome Discovery of Genes in the Three Phases of Autophagy That Are Upregulated During Atrial Fibrillation
Takahiro Kamihara, Akihiro Hirashiki, Manabu Kokubo, Atsuya Shimizu
Abstract
Background: Autophagy may contribute to the maintenance of atrial fibrillation (AF), but no previous study has concurrently surveyed all 3 phases of autophagy, namely autophagosome formation, lysosome formation, and autophagosome-lysosome fusion. Here we aimed to identify disorders involving various phases of autophagy during AF.
Topics & Concepts
AutophagyLysosomeAutophagosomeATG5Cell biologyTFEBBiologyDownregulation and upregulationTranscriptomeGeneGene expressionBiochemistryApoptosisEnzymeAutophagy in Disease and TherapyExtracellular vesicles in diseaseStudies on Chitinases and Chitosanases