Design and evaluation of novel piperidine HIV-1 protease inhibitors with potency against DRV-resistant variants
Mei Zhu, Huiyu Zhou, Ling Ma, Biao Dong, Jinming Zhou, Guoning Zhang, Minghua Wang, Juxian Wang, Shan Cen, Yucheng Wang
Topics & Concepts
ChemistryPiperidineHIV-1 proteaseStereochemistryLigand (biochemistry)ProteaseIC50PotencyEnzymeHydrogen bondEnzyme inhibitorEC50In vitroBiochemistryOrganic chemistryMoleculeReceptorHIV/AIDS drug development and treatmentHIV Research and TreatmentHIV/AIDS Research and Interventions