A Tight Contact: The Expanding Application of Salicylaldehydes in Lysine‐Targeting Covalent Drugs
Mattia Mason, Laura Belvisi, Luca Pignataro, Alberto Dal Corso
Abstract
The installation of aldehydes into synthetic protein ligands is an efficient strategy to engage protein lysine residues in remarkably stable imine bonds and augment the compound affinity and selectivity for their biological targets. The high frequency of lysine residues in proteins and the reversibility of the covalent ligand-protein bond support the application of aldehyde-bearing ligands, holding promises for their future use as drugs. This review highlights the increasing exploitation of salicylaldehyde modules in various classes of protein binders, aimed at the reversible-covalent engagement of lysine residues.
Topics & Concepts
Covalent bondLysineChemistrySalicylaldehydeImineCombinatorial chemistryAldehydeLigand (biochemistry)SelectivityBiochemistryStereochemistryOrganic chemistryReceptorSchiff baseAmino acidCatalysisMonoclonal and Polyclonal Antibodies ResearchPeptidase Inhibition and AnalysisClick Chemistry and Applications