Direct radical alkylation and acylation of 2<i>H</i>-indazoles using substituted Hantzsch esters as radical reservoirs
Li Liu, Pengxing Jiang, Yongguo Liu, Hongguang Du, Jiajing Tan
Abstract
A platform approach for the direct synthesis of 3-substituted 2<italic>H</italic>-indazole derivatives has been developed using a Ag(<sc>i</sc>)/Na<sub>2</sub>S<sub>2</sub>O<sub>8</sub> system.
Topics & Concepts
ChemistryIndazoleAcylationAlkylationRadical cyclizationMedicinal chemistryOrganic chemistryCatalysisRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques