Pharmacological Elevation of Cellular Dihydrosphingomyelin Provides a Novel Antiviral Strategy against West Nile Virus Infection
Nereida Jiménez de Oya, Ana San‐Félix, Mireia Casasampere, Ana-Belén Blázquez, Patricia Mingo‐Casas, Estela Escribano-Romero, Eva Calvo-Pinilla, Teresa Poderoso, Josefina Casas, Juan‐Carlos Sáiz, María‐Jesús Pérez‐Pérez, Miguel A. Martín-Acebes
Abstract
)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide} confirmed the involvement of this pathway in WNV infection. These results unveil the potential of novel antiviral strategies based on the modulation of the cellular levels of dhSM and Des1 activity for the control of flavivirus infection.
Topics & Concepts
West Nile virusGallic acidFlavivirusLipid metabolismVirologyCellular metabolismVirusBiologyPolyphenolMetabolismChemistryBiochemistryAntioxidantMosquito-borne diseases and controlViral Infections and VectorsPlant Virus Research Studies